Smoking, the first and foremost cause of lung cancer, is accountable for about 80 to 90% of the cases and compromise risk factors for cancers of the bladder, pancreas, oral cavity, larynx, esophagus, and kidneys. Cigar smoking causes cancer of the lungs, mouth, larynx, and esophagus. Other suggestive evidence is second-hand smoke causing cancer in adults and children. E-smoke, however, has comparatively unestablished and under-design study for its long-term health effects.